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Leucine

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Leucine is one of the most important branched-chain amino acids (BCAAs), playing a key role in building muscle mass, recovering from training, and improving physical performance. It is an EAA amino acid, meaning the body cannot synthesize it on its own, so it must be obtained through diet or supplements. Leucine stands out from other amino acids for its ability to activate anabolism. This allows leucine to directly support muscle growth and repair after intense physical exercise. Leucine effectively shortens recovery time and reduces muscle soreness after training. Choose the best amino acids for building muscle mass.

What is Leucine? The Queen of BCAA Amino Acids

Leucine is one of the three branched-chain amino acids (BCAAs), along with isoleucine and valine. Although all three work synergistically, leucine is the undisputed leader and most important player on this team. Why? Because it serves as the main anabolic signaling device.

Imagine your muscles are a construction site. Protein is the bricks, and the workers are the biochemical processes in your body. Leucine is the construction supervisor in this scenario, shouting, "LET'S BEGIN!

". Without this signal, even with the best materials (protein), work won't get off to a flying start. Leucine directly activates a key metabolic pathway in muscle cells, known as the mTOR pathway (mammalian target of rapamycin).

The mTOR Pathway – Your Personal Anabolic Switch

Activating the mTOR pathway is the holy grail for anyone who wants to build muscle. It's a cascade of biochemical reactions that gives muscle cells the green light to initiate muscle protein synthesis (MPS).

Simply put, mTOR tells your muscles to take available amino acids and use them to repair damaged muscle fibers and build new, bigger, and stronger ones.

And this is where leucine plays its key role. Of all the amino acids, it stimulates mTOR the most strongly. You can eat tons of protein, but if your meal lacks the right amount of leucine (the so-called "leucine threshold"), the signal to start building muscle will be too weak. That's why supplementing with pure leucine or products high in it is so damn effective.

Benefits of Leucine

Maximizing Muscle Gains

This is the most important and best-documented effect of leucine. By activating the mTOR pathway, leucine initiates and enhances the process of muscle protein synthesis. Every strength training session you perform causes micro-damage in muscle fibers. Leucine is key to their effective hypertrophy. Adding a serving of leucine to your post-workout meal or protein supplement is like pouring rocket fuel into your engine – the building process starts immediately and with maximum power.

Powerful Anti-Catabolic Protection

Catabolism is your number one enemy. It's the process of muscle tissue breakdown, which intensifies during intense exercise, during a cutting phase (calorie deficit), or even at night. Leucine acts as a protective shield for your muscles. It reduces the activity of enzymes responsible for the breakdown of muscle proteins, protecting what you've worked so hard to achieve. That's why it's essential for dieters who want to burn fat, not muscle.

Leucine Accelerates Recovery

The faster you recover, the faster you can return to the gym and perform another, even harder session. By initiating repair processes, leucine significantly shortens the time needed for recovery. Less "soreness" (actually delayed onset muscle soreness – DOMS), faster recovery, and readiness for action – these are the standard effects of regular leucine use.

Improved Insulin Sensitivity and Supported Fat Loss

Leucine also plays a role in glucose metabolism. It may improve cell sensitivity to insulin, meaning your body uses carbohydrates more efficiently as an energy source instead of storing them as fat. While it's not a typical "fat burner," its effects on blood sugar and metabolism properties make it invaluable support during cutting periods.

Dosage of the amino acid leucine

Supplementation is not a secret art, but a science. For leucine to work at its full potential, you need to know when and how to take it.

When should you take leucine?

Remember, leucine acts like a switch. You need to use it at key moments.

  1. Peri-Workout (Before and After Workout): This is absolutely the most important time. A serving of leucine taken about 30 minutes before training will prepare your muscles for exercise and provide anti-catabolic protection. A serving immediately after training is the strongest possible signal to initiate regeneration and anabolism. Combining leucine with carbohydrates and protein (e.g., in the form of a shake) after training is an anabolic masterpiece.
  2. Morning, on an empty stomach: After sleeping overnight, your body is in a state of light catabolism. A quick dose of leucine immediately interrupts this process and switches your body into anabolic mode, protecting your muscles.
  3. As a Supplement to Low-Leucine Meals: Not every meal is ideal in terms of your amino acid profile. If you eat a meal based primarily on plant proteins or simply want to ensure you're exceeding your "leucine threshold," adding 2-3 grams of pure leucine to your meal is a brilliant and simple way to boost its anabolic potential.

Recommended Leucine Doses

Scientific research and years of practice show that an effective single serving of leucine that can maximize muscle protein synthesis is between 3 and 5 grams.

  • Standard Serving: 5 grams.
  • Total Daily Dose: Depending on your training intensity and goals, you'll typically need 5 to 15 grams of leucine per day, divided into 2-3 servings.

What to take the amino acid leucine with?

Leucine is powerful on its own, but it becomes even more effective in the right combination.

  • With Other BCAAs (Isoleucine and Valine): Although leucine is the most important, the other BCAAs also play their roles, including as an energy source for muscles. The classic BCAA combination is always a good choice.
  • With Protein Powder (Especially Whey): Adding leucine to your post-workout protein shake is the best way to maximize protein synthesis. Whey protein is already rich in leucine, but an additional serving acts as a "trigger" that intensifies the effect.
  • With Creatine: It's a combination of titans. Leucine initiates muscle building, and creatine provides energy (in the form of ATP) for this process and increases strength and endurance. Together, they form the foundation of supplementation for anyone serious about strength results.
  • With Carbohydrates: Consuming carbohydrates (especially simple ones) after a workout causes an insulin spike. Insulin is the most powerful anabolic hormone in the body and acts as a transporter that "pushes" leucine and other amino acids directly into muscle cells.

What is the difference between leucine and BCAAs?

Although leucine is a component of BCAAs (along with isoleucine and valine), it is leucine that is the key ingredient with anabolic effects. This means that supplementing with leucine alone may be more effective than using classic BCAAs – especially if you want maximum support for muscle building.

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