Smart Brothers DIHEXA 30 caps

Smart Brothers DIHEXA 30 caps - PNB-0408 - nootropic supplement

Nootropic supplement Smart Brothers DIHEXA 30 caps, also known as PNB-0408 is a product that has a cognitive supporting effect. More and more people are looking for ways to support their brain and optimize cognitive functions. In this context, nootropics come to the forefront - substances that are designed to improve cognitive functions such as memory, concentration, creativity or motivation, without significant side effects.

How does DIHEXA work on the brain?

DIHEXA (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is an analogue of the natural neuropeptide angiotensin IV, designed to bypass the blood-brain barrier and act directly on brain receptors. Its mechanism is based on increasing the expression of neurotrophic factors such as BDNF (Brain-Derived Neurotrophic Factor), which translates into:

• improving long-term and short-term memory,
• faster information acquisition,
• increased neuroplasticity,
• accelerated neuronal regeneration.

DIHEXA was developed by scientists at Washington State University as a potential therapeutic agent, originally studied for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's.

BDNF - essential support for brain function

BDNF, or brain-derived neurotrophic factor, is a protein that plays a key role in the life of neurons - nerve cells in our brain.4 It can be compared to a "fertilizer" or "growth factor" for the brain. BDNF is involved in:

• Neurogenesis: The process of creating new neurons.
• Neuroprotection: Protecting existing neurons from damage and death.
• Synaptic plasticity: The ability of connections between neurons (synapses) to strengthen or weaken, which is the basis of learning and memory.5
• Growth and neuronal differentiation: Helps neurons grow and develop properly.

Low BDNF levels are often observed in neurodegenerative diseases, depression, anxiety and cognitive problems. BDNF activity is therefore essential for maintaining brain health, improving learning, memory and mood.

How does DIHEXA affect BDNF levels?

DIHEXA is not BDNF itself, but acts as a BDNF mimetic. This means that it mimics the action of BDNF by binding to the same receptor in the brain as natural BDNF. This receptor is the TrkB (tropomyosin receptor kinase B) receptor. When DIHEXA binds to this receptor, it activates signaling pathways within neurons, similar to how BDNF would do. This activation leads to a cascade of events that support neuronal health and function. DIHEXA has the potential advantage over BDNF itself in that, as a smaller peptide, it may have a better ability to cross the blood-brain barrier, reaching where it is needed.

DIHEXA - the effects of a nootropic supplement

Stimulation of neuronal growth

Activation of the TrkB receptor by DIHEXA can stimulate neurogenesis, the formation of new nerve cells, especially in areas of the brain that are key to memory and learning, such as the hippocampus. At the same time, activation of these pathways has a neuroprotective effect, helping to protect existing neurons from oxidative stress, inflammation, and other damaging factors. It's like watering and fertilizing plants - it supports their growth and protects them from pests.

Improving Neural Plasticity

Synaptic plasticity is the foundation of our ability to learn and remember.7 When we learn something new, the connections between the neurons involved in the process become stronger or new connections are formed.8 Activation of the TrkB receptor by DIHEXA may enhance these processes, facilitating the formation and consolidation of memory traces. Imagine that synapses are paths in a forest - the more you use them (learn them), the clearer and easier they become. DIHEXA may help to “clear” these pathways.

Effects on Neurotransmitters

Although the primary mechanism of DIHEXA focuses on BDNF pathways, activation of these pathways may secondarily affect the levels and function of certain neurotransmitters, such as acetylcholine, dopamine, and serotonin. These neurotransmitters play a key role in regulating mood, motivation, concentration, and other cognitive functions. Improving their balance can translate into better well-being and mental performance.

Impact on mood and stress resistance

BDNF is also involved in regulating mood and stress response.9 Studies indicate that low levels of BDNF are associated with depression and anxiety.10 By mimicking the effects of BDNF, DIHEXA can potentially improve mood and increase mental resistance to stress factors.11 It's like strengthening your brain's "immune system" to negative experiences.

Smart Brothers DIHEXA - nootropic dosage

1 serving, 1 capsule daily.