Smart Brothers GHK-Cu 60 caps

Smart Brothers N-Acetyl GHK-Cu 60 caps – copper peptide in capsules

GHK-Cu copper peptide is generating immense interest in the world of supplementation and cosmetology. Its action is confirmed by scientific research, and the experiences of thousands of people show a real impact on skin appearance, hair condition, and the body's regenerative processes. Smart Brothers GHK-Cu is an acetylated form of the peptide, which allows for a convenient way to deliver the copper peptide to the body.

The effects of Smart Brothers GHK-Cu include:

• Enhanced collagen production: Skin becomes firm, elastic, and smooth.
• Hair regeneration: Stimulation of growth, thickening of the hair shaft, and fighting hair loss.
• Fast healing: Accelerated repair of wounds and injuries, and reduction in the visibility of scars.
• Anti-inflammatory action: Reduction of inflammation throughout the body, providing support for the joints.
• Antioxidant protection: Neutralization of free radicals and protection of DNA from damage.
• Improved complexion quality: Combatting discoloration, photoaging, and a dull skin tone.

What is GHK-Cu and how does its acetylated form work?

GHK-Cu (Gly-His-Lys-Cu) is copper tripeptide-1 – three amino acids (glycine-histidine-lysine) bound to a copper ion.

Sounds complicated? Think of it as a courier that transports copper directly into the cells. Copper is a key cofactor for hundreds of repair enzymes in the body. Without it, you cannot build collagen, neutralize free radicals, or create new blood vessels.

However, ordinary copper from the diet often doesn't reach its intended destination. Most of it gets bound by proteins in the blood or excreted by the liver before it reaches fibroblasts or muscle cells.

GHK-Cu bypasses this problem—delivering it directly to the cells.

“Genetic Reset” – science or science fiction?

In 2010, researchers from the Broad Institute discovered something remarkable: GHK-Cu affects the expression of over 4,000 genes in human fibroblasts.

Specifically:

• It activates 1,309 genes responsible for: collagen synthesis, DNA repair, angiogenesis, and mitochondrial function.
• It silences 1,299 genes responsible for: inflammation, oxidative stress, and connective tissue breakdown.

The result? Cells begin to behave like younger versions of themselves. This isn't just "supporting" functions – it’s a reprogramming of the genetic profile closer to what you have at age 20-30.

Why N-Acetyl? The advantage over regular GHK-Cu peptide

This is the question that determines whether your supplement will actually work.

The Problem: The stomach destroys peptides

Peptides are chains of amino acids linked by peptide bonds. These bonds are extremely sensitive to stomach acids and digestive enzymes.

When you swallow regular GHK-Cu:

1. Stomach pH (1.5-3.5) begins to destabilize the structure.
2. Pepsin (a digestive enzyme) breaks the peptide bonds.
3. Only 5-10% of intact molecules remain (in the best-case scenario).

The rest of the peptide? Broken down into individual amino acids, which no longer possess the regenerative properties of GHK-Cu.

The Solution: Acetylation

N-Acetyl GHK-Cu has an acetyl group (CH₃CO) attached to the N-terminal end of the peptide.

This acts like protective armor:

• The acetyl group blocks digestive enzymes from accessing sensitive peptide bonds.
• It changes the charge of the molecule, facilitating penetration through the intestinal membrane.
• It increases stability in acidic environments (the peptide “survives” the stomach).

Mechanism of Action for Smart Brothers GHK-Cu

Skin, Hair, and the “Ironing Effect”

GHK-Cu doesn't just “smooth wrinkles” superficially. It rebuilds the skin structure from within.

1. Stimulation of Fibroblasts

Fibroblasts are the “collagen factories” in the skin. GHK-Cu:

• Increases their metabolic activity (more energy = more production).
• Stimulates the synthesis of Type I and III collagen (the main types in adult human skin).
• Promotes the production of elastin (responsible for bounce and elasticity).

Visual effect: Denser, firmer skin. Wrinkles appear shallower, and facial contours are better defined.

1. Connective Tissue Remodeling

This is a dual-track process:

• Removing old collagen: GHK-Cu activates metalloproteinases (MMPs), which break down old, stiffened collagen.
• Building new collagen: Fibroblasts produce fresh, flexible collagen.

It’s like replacing old wallpaper with new. You don't just paint over the old space—you strip away the damaged layer and lay down a new one.

1. Hair: More than just "thickness"

GHK-Cu influences the hair follicles:

• Increases the size of miniaturized follicles (the reverse process of androgenetic alopecia).
• Improves blood supply to the scalp (angiogenesis – see below).
• Extends the anagen phase (the hair growth phase).

DNA Regeneration, Mitochondria, and Angiogenesis

At this point, GHK-Cu stops being just a “cosmetic” and becomes a tool for systemic regeneration.

1. Repair of Damaged DNA

Research by Dr. Pickart shows that GHK-Cu:

• Activates genes responsible for DNA repair.
• Silences pro-inflammatory and pro-gerotoxical genes.
• Protects telomeres (the ends of chromosomes, the shortening of which causes cell aging).

The result? Cells live longer and function more efficiently.

1. Mitochondria: "Cellular Power Plants"

GHK-Cu improves mitochondrial function by:

• Reducing oxidative stress (neutralization of free radicals).
• Improving the integrity of mitochondrial membranes.
• Supporting ATP production (cellular energy).

Practical effect: More energy, better post-workout regeneration, and faster healing of micro-injuries.

1. Angiogeneza: Building New Vessels

This is a key mechanism for athletes and people recovering from injuries.

GHK-Cu stimulates the formation of new blood vessels (capillaries) around damaged tissues. More vessels = better blood flow = faster delivery of oxygen and building blocks = faster healing.

Studies show a 47% increase in capillary density in damaged tissues after using GHK-Cu.

Usage and dosage of GHK-Cu in capsules

Recommended dosage: 1 capsule daily

When to take: In the morning, on an empty stomach or with a light meal (the peptide does not require fats for absorption)

Duration of use: Minimum 8-12 weeks for full regenerative effects

Copper-Zinc Balance

Copper and zinc are antagonists. An excess of one flushes out the other.

When you supplement with GHK-Cu (supplying copper), your body automatically loses zinc. If you do not compensate for this deficit, you may experience:

• Chronic fatigue
• Brain fog
• Weakened immunity
• Worsened wound healing (a paradox!)

What to do?

Zinc supplementation is mandatory during a GHK-Cu cycle.

Zinc dosage:

• 15-30 mg daily (form: zinc picolinate or gluconate)
• In the evening, separately from GHK-Cu (e.g., GHK-Cu in the morning, zinc before bed)