Haya TMG Trimethylglycine 100 tabs - support for methylation processes
Haya TMG Trimethylglycine is a dietary supplement providing a high dose of betaine anhydrous, which supports, among other things, important methylation processes in your body. What's more, it is responsible for energy metabolism and maintains an appropriate level of hydration. Check why it is worth using and what health benefits it will bring you.
What is TMG?
Trimethylglycine (TMG), also known as betaine anhydrous, is an organic compound belonging to the betaine group. TMG occurs naturally in many plants, especially in sugar beets (where the name "betaine" comes from), spinach, cereals and seafood. In the human body, TMG is synthesized endogenously in small amounts, but the main source remains the diet.
In biochemical terms, TMG plays two key roles: as an osmolyte, protecting cells from osmotic stress, and as a methyl donor in the methylation process. The latter function is of particular interest in the context of human health and the potential benefits of supplementation.
Role of TMG as a Methyl Donor
The most important biochemical role of TMG in the body is its participation in the methylation process. Methylation is a fundamental biochemical reaction that involves the transfer of a methyl group from one molecule to another. This process is crucial for many vital functions, including DNA and RNA synthesis, neurotransmitter metabolism, detoxification, creatine synthesis, and most importantly, homocysteine metabolism. TMG works in the methionine cycle, where it transfers a methyl group to homocysteine, converting it to methionine. This reaction is catalyzed by the enzyme betaine-homocysteine methyltransferase (BHMT) and is particularly active in the liver and kidneys.
Trimethylglycine lowers homocysteine
One of the best-documented effects of TMG supplementation is its ability to lower homocysteine levels in the blood. Homocysteine is a sulfur amino acid that, in high concentrations, is considered an independent risk factor for cardiovascular diseases such as atherosclerosis, heart attack, or stroke. The mechanism by which elevated homocysteine contributes to these conditions is not fully understood, but it involves damaging the endothelium of blood vessels, promoting thrombosis, and inflammation. TMG effectively lowers cysteine levels, which has been linked to its health-promoting effects in this area.
TMG supports liver function
The liver is the primary organ for homocysteine metabolism via the enzyme BHMT and TMG. TMG plays a key role in the detoxification and metabolism of fats in the liver. Studies suggest that TMG may help protect the liver from damage, including fatty liver disease (both alcoholic and nonalcoholic), by improving lipid metabolism and reducing oxidative stress. As a methyl donor, TMG can also support detoxification processes in the liver that require methylation reactions.
TMG in sports supplementation
TMG is gaining popularity among athletes and physically active people due to its potential to improve performance. The mechanism of action in this context is complex. First, TMG can support creatine production. Creatine is an important source of energy for muscles during intense exercise. In the body, creatine is synthesized from methionine, glycine, and arginine. Since TMG increases the methionine pool via homocysteine conversion, this may promote increased creatine synthesis.
TMG Improves Hydration
Second, TMG as an osmolyte may help maintain muscle cell hydration, which may impact muscle function and endurance. Studies on the effects of TMG on physical performance have yielded mixed results, but some suggest potential benefits for strength, power, and endurance, especially during resistance training.
Trimethylglycine supports cognitive function
The methylation process, in which TMG is involved, is crucial for the synthesis and metabolism of neurotransmitters such as serotonin, dopamine, and norepinephrine, which play important roles in regulating mood, motivation, and cognitive function. Low levels of methylation may be associated with mood disorders. By supporting methylation processes, TMG may indirectly affect neurotransmitter balance and potentially alleviate symptoms of depression and anxiety.
Haya TMG Trimethylglycine dosage
2-3 tablets daily.