Haya Agmatine Sulfate 500mg 60 caps is a very strong no-booster that will maximize your muscle pump!
Haya Agmatine Sulfate 500mg 60 caps is a dietary supplement in capsules containing high-quality agmatine sulfate. Its spectrum of action allows you to improve the quality of your workouts and muscle pumps, as well as having a beneficial effect on the nervous system. Agmatine is often described as "super arginine". Its action intensifies the effect of muscle pumps, which can be felt even after 500 mg! As you can see, this is a much lower dose than in the case of classic arginine-based no-boosters. However, agmatine has additional functions which perfectly support the physical effort.
Effects of Haya Agmatine Sulfate:
- A powerful no-booster,
- Enhances nitric oxide synthesis,
- Supports the nervous system,
- Nootropic effect,
- Improves endurance,
- Supports well-being,
- Increases training intensity.
Nitric oxide and muscle pump
Nitric oxide, as a gaseous hormone, has a fairly broad effect on the body, but its effects vary depending on where it is produced. In different tissues, the respective isoforms of the enzyme nitric oxide synthase, which converts arginine into NO, are active. Athletes value arginine mainly for its effective intensification of the feeling of a muscle pump, which results from widening the lumen of blood vessels and the resulting more efficient influx of nutritional blood into muscles. The eNOS form of the enzyme is responsible for the increase in nitric oxide in blood vessels, and it is its activity that is enhanced by agmatine. The other two forms, nNOS, and iNOS are inhibited by agmatine, which is also good news because excess nitric oxide in nerve tissue, for example, is destructive.
Agmatine may also protect neurons through mechanisms other than the aforementioned inhibition of neuronal nitric oxide. The most prominent neuroprotective mechanism is NMDA receptor inhibition. Excessive activation of these receptors by glutamate and/or other molecules risks excessive migration of calcium ions into neurons, resulting in excitotoxicity, or cell death resulting from overexcitation. Similarly, blocking these receptors protects us from nerve cell destruction.
Agmatine is a neurotransmitter
The glutamatergic system is not the only system that agmatine acts on. Another system is the adrenergic system, specifically the alpha2 receptor subtype. The effect on these receptors is dose-dependent, as in small amounts agmatine is merely a modulator and can enhance the transmission of neurotransmitters that bind this receptor, while in larger amounts it becomes a competitive inhibitor. What many people should find interesting is that agmatine has documented antidepressant effects. This is largely due to its effects on serotonin, the happiness molecule. Agmatine does not increase the concentration of serotonin in synapses, but it does affect the action of some of its receptors, particularly the 5-HT-2 subtypes.
Activation of imidazoline receptors, in turn, causes an increased release of beta-endorphins, which are natural pain reducers and mood enhancers in an almost euphoric way.
Improving sensitivity to stimulants
The use of agmatine is a popular practice to not only build a tolerance to stimulants more slowly but also as part of rebuild sensitivity to their effects. This is especially beneficial for people who complain about the poor effects of caffeine and other stimulants. This effect is also confirmed in scientific studies, which examined the effect of NMDA inhibitors on building tolerance to the effects of cocaine and amphetamine, but also various other psychoactive agents, not only stimulants.
One of the factors that reduce pain sensation is the aforementioned increase in beta-endorphins, resulting from the activation of imidazoline receptors. Effects on these same receptors result in increased transmission at CB1 receptors of the cannabinoid system, so agmatine may enhance the inelastic effects of marijuana and endocannabinoid enhancers. Through nNOS inhibition and NMDA inhibition, agmatine not only potentiates the effects of opioid drugs such as morphine and fentanyl but also slows the decline in their effects resulting from rapidly building tolerance. This makes it possible to use lower doses and protect your health from the harmful effects of these types of drugs. Agmatine is also effective on its own in reducing neuropathic pain.
Agmatine is recommended for athletes looking for an effective way to increase blood supply and muscle nutrition during training. It is also great for preventing rapidly increasing stimulant tolerance. It can also be used by those struggling with depressive symptoms.
1 serving, 2 capsules:
Agmatine Sulfate - 1000 mg - agmatine sulfate is a neuroactive molecule produced in the body from arginine, through a decarboxylation reaction. It is particularly interesting due to its NMDA receptor blocking and nitric oxide synthesis modulating properties. It is most commonly used as part of pre-workout supplementation and as a support in the fight against addiction. Agmatine is highly active even in small doses. Many people feel its strong effects at 500 up to a maximum of 1500 mg per serving.
Recommended Dosage: Take 2 capsules 30 minutes before workout.