FOCUSED NUTRITION Elite MK-677 is an oral anabolic-anti-catabolic agent based on Ibutamoren, a ghrelin mimetic, whose action allows to increase the concentration of growth hormone (GH, somatotropin) and insulin-like growth factor 1 (IGF-1) and reduce the amount of cortisol in the body.
Growth hormone - a peptide hormone produced by cells located in the glandular part called somatotropes. He is responsible for a number of important processes taking place in the body, including: the development of the system, energy substrate management, the degree of anabolic and catabolic changes, immune response and the work of the central nervous system. The regulation of periodic secretion of somatropin is administered by somatoliberins, somatostatin and IGF-1, and among the stimuli increasing its secretion, the most frequently mentioned are: physical exercise, sleep, adequate amino acids supply, hunger and the accompanying ghrelin and availability of some other hormones. GH induction leads to intensification of amino acid uptake by muscles, reduction of proteolysis, increase of mRNA transcription and translation rate, intensification of lipolysis process, reduction of insulin resistance and improvement of insulin function, promotion of skeletal growth and stimulation of antibody formation and maturation of macrophages. The consequence of the activity of somatropin is the synthesis and renewal of muscle fibers, the construction of strong bone and the decay of adipose tissue.
Ibutamoren, acting on the receptors of growth hormone secretagogues (GHS-R), allows to increase the concentrations of GH, IGF-1 and the insulin-like growth factor-3 binding protein (IGFBP-3) necessary for its proper functioning. The ability to activate the GHS-R was attributed to ghrelin. The imitation of ghrelin in this area allowed the classification of Ibutamoren as a grelinomimetic.
Grelin - a peptide hormone secreted from preprogrelin, largely secreted from the stem and gout cell lining cells, which, demonstrating the ability to stimulate the appetite and support the digestive system, allows the maintenance of a positive energy balance and protection of the body's energy reserves. As a GHS-R ligand enabling their activation, it intensifies GH and IGF-1 ejection. It allows you to activate the AKT / mTOR pathway, increase the number of satellite cells, as well as reduce inflammation and reduce myostatin activity, thus engaging in muscle and bone development processes. Its growth properties are limited by its increase in concentrations: cortisol and prolactin - a hormone limiting the synthesis of luteinizing hormone (LH) and testosterone.
MK-677, unlike ghrelin, does not increase the level of cortisol, even reduces its amount. In addition, it does not change the concentration of prolactin and luteinizing hormone (LH). In some cases, it can lead to a reduction in total testosterone, but without interference in the amount of free testosterone.
FOCUSED NUTRITION Elite MK-677 is an anabolic-anti-catabolic product that, as one of the few on the market, significantly increases the level of growth hormone without the need for its injection into the body. By increasing the amount of GH, IGF-1 and lowering cortisol, it creates ideal conditions for the development of muscle tissue and bone reinforcement. Supporting the loss of excess body fat, it allows you to display details and the presentation of a separated silhouette.
3 capsules daily 30 minutes before bedtime.